The Strait of Belle Isle ecoregion occupies the northern tip of the Northern Peninsula. It is characterized by cool summers and cold winters.

This ecoregion extends across the southern Labrador border with Quebec and runs northwest to the southern boundary of the Smallwood Reservoir.

The Paradise River ecoregion is located in the southeastern section of Labrador.

South Avalon Burin Oceanic Barrens ecoregion covers the southern tips of the Avalon and Burin peninsulas.

The Torngat Mountains ecoregion is located in the northernmost part of Labrador.

This ecoregion extends northeast from Winokapau Lake and borders the western extensions of the Lake Melville ecoregion.